Enhancing cisplatin delivery to hepatocellular carcinoma HepG2 cells using dual sensitive smart nanocomposite
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منابع مشابه
In Vitro Challenge using Thymoquinone on Hepatocellular Carcinoma (HepG2) Cell Line
Black seed (Nigella sativa) is considered as a biological response modifier. Thymoquinone (TQ) is the bioactive and the most abundant constituent of the volatile oil of this seed which has been shown to possess anti-inflammatory, antioxidant and anti-neoplastic effects. In this study, the effect of TQ on HepG2 cell line was investigated in an attempt to identify its potential mechanism of actio...
متن کاملIn Vitro Challenge using Thymoquinone on Hepatocellular Carcinoma (HepG2) Cell Line
Black seed (Nigella sativa) is considered as a biological response modifier. Thymoquinone (TQ) is the bioactive and the most abundant constituent of the volatile oil of this seed which has been shown to possess anti-inflammatory, antioxidant and anti-neoplastic effects. In this study, the effect of TQ on HepG2 cell line was investigated in an attempt to identify its potential mechanism of actio...
متن کاملEffect of Mst1 overexpression on the growth of human hepatocellular carcinoma HepG2 cells and the sensitivity to cisplatin in vitro.
Mammalian STE20-like kinase 1 (Mst1) is the mammalian homologue of Drosophila Hippo, a major inhibitor of cell proliferation in Drosophila. It ubiquitously encodes serine threonine kinase that belongs to the family of protein kinases related to yeast STE20, and is involved in cell proliferation, apoptosis, oncogenesis, and organ growth. Recent studies have shown that Mst1 has tumor-suppressor f...
متن کاملANTICANCER ACTIVITY OF Artemisia vulgaris ON HEPATOCELLULAR CARCINOMA (HEPG2) CELLS
Hepatocellular carcinoma is the fifth leading cancer causing death worldwide. Currently research focuses on the use of medicinal plants for the treatment of cancer, due to its resistance to chemotherapeutic agents. Objective: The present study pertains to the use of Artemisia vulgaris as a source of anticancer agent. The methanolic extract of the leaves were tested in vitro against HepG2 (hepat...
متن کاملSynergistic combinations of tanshinone IIA and trans-resveratrol toward cisplatin-comparable cytotoxicity in HepG2 human hepatocellular carcinoma cells.
AIM To determine the combinative effects of tanshinone IIA (Tan IIA) and trans-resveratrol (Resv) on cytotoxicity, apoptosis, cell-cycle arrest and DNA fragmentation in HepG2 human liver cancer cells. MATERIALS AND METHODS Cytotoxicity was detected by the cell proliferation and cytotoxicity WST-1 assay. Cell-cycle arrest and apoptosis were determined using flow cytometry analysis. DNA fragmen...
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ژورنال
عنوان ژورنال: Artificial Cells, Nanomedicine, and Biotechnology
سال: 2017
ISSN: 2169-1401,2169-141X
DOI: 10.1080/21691401.2017.1349777